TAR DNA BINDING PROTEIN-43 LOSS OF FUNCTION INDUCED BY PHOSPHORYLATION AT S409/410 BLOCKS AUTOPHAGIC FLUX AND PARTICIPATES IN SECONDARY BRAIN INJURY AFTER INTRACEREBRAL HEMORRHAGE

This study aimed to determine the role of TAR DNA binding protein-43 (TDP-43) in intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI) and its underlying mechanisms.After ICH, expression of TDP-43 in the nucleus was significantly decreased, and its expression in the cytoplasm increased both in vivo and in vitro, which indicates that T

jerome brown jersey Jiska M Balk,1 Guido RMM Haenen,1 Özgür M Koc,2 Ron Peters,3 Aalt Bast,1 Wim JF van der Vijgh,1 Ger H Koek,4 1Department of Toxicology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, 2Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, 3DSM Re

Pozzolanic concrete has superior properties, such as high strength and workability.The precise proportioning and modeling of the concrete mixture are important when considering its applications.There have been many efforts to develop computer-aided approaches for pozzolanic concrete mix design, such as artificial neural network- (ANN-) based approa

Barbados aloe (Aloe vera (L.) Burm.f.) has traditionally been used for healing in natural medicine.However, aloe is now attracting great interest in the global market due to its bioactive chemicals which korpskaft are extracted from the leaves and used in industrial preparations for pharmaceutical, cosmetic and food products.Aloe originated from tr